Police say the road is closed between Sinnington and Keldholme
North Yorkshire Polcie say they are currently dealing with "a serious RTC" on the A170 between Sinnington and Keldholme.
The A170 was closed just after 3:30pm on Thursday and is expected to be closed for some time.
Officers say:
"Motorists travelling between Pickering and Kirkbymoorside should find an alternative route."
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Scarborough Athletic supporters will be planning the next nine months of football action as the National North fixtures arrived on Friday.
The Yorkshire Coast has missed out on the chance to host the UK's first Town of Culture after bids from Whitby, Scarborough, Bridlington, Driffield, and Pickering failed to make the final shortlist.
The Seasiders welcome Whitby Town to the Mounting Systems Stadium on Friday.
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